Tumor lysis syndrome associated with nivolumab plus ipilimumab combination therapy in a melanoma patient Dear Editor, A 45-year-old man, who was referred to our clinic for an expanding melanotic macule on his abdomen, was diagnosed with malignant melanoma (T3aN0M0, stage IIA) based on a skin biopsy. Surgical removal of his tumor was performed. Five years after his first surgical procedure, inguinal and external iliac lymph node metastases were discovered and lymph node dissection was performed. Many tumor-infiltrating lymphocytes (TIL) were found in the metastatic lesions. The TIL profile consisted of cells that were positive for CD8, programmed death 1