Purpose: Soft tissue sarcomas (STS) account for 8% of all cancers in adolescents and young adults (AYAs). Metastatic STS contribute significantly to disease-related mortality in this age group; however, data are limited due to under-representation in clinical trials. Methods: AYAs aged 18–39 years, diagnosed with metastatic STS between 1990 and 2012, were identified from The Royal Marsden Hospital database. Outcomes of interest were clinical characteristics, treatment patterns, overall survival (OS), and prognostic factors. Results: Overall, 455 patients were included. Median age at diagnosis of metastatic STS was 33 years (interquartile range [IQR] 27–37 years). The most common histological subtypes were leiomyosarcoma ( n = 68, 15%), synovial sarcoma ( n = 68, 15%), Ewing sarcoma ( n = 44, 10%), and rhabdomyosarcoma ( n = 35, 8%). Treatments included systemic therapy ( n = 395, 87%; median 2 lines [IQR 1–3]; clinical trial n = 93, 22%), radiotherapy ( n = 297, 66%), and metastasectomy ( n = 191, 43%). Median duration between last chemotherapy regimen and death was 4.6 months (IQR 2–10). Median OS was 19.2 months (95% confidence interval [CI] 15.8–22.2); 5-year OS was 16%. Of common subtypes, patients with rhabdomyosarcoma had the worst OS (8.8 months; 95% CI 7.9–11.4). Adverse prognostic factors included male gender, synchronous metastases, bone or liver metastases, first-line polychemotherapy, and no metastasectomy. Conclusions: Outcomes were variable; patients with supposed chemosensitive subtypes had particularly poor survival. The diverse behavior of STS in AYAs highlights the need for subtype-specific clinical trials.

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S-adenosyl-l-methionine, non-competitive PRC2 inhibitor that impairs EED binding to tri-methylated lysine 27 on histone H3 (H3K27me3), preventing allosteric activation of this complex. This is a phase I/II study of MAK683, in adult pts with advanced malignancies who have exhausted or have no effective standard treatment. The primary objective was to characterize safety and tolerability and determine the maximum tolerated dose and/or recommended phase II dose.Methods: Pts received escalating doses of MAK683 in fasted conditions where appropriate. Eligible pts had specified advanced/metastatic hematological or solid malignancies. Here, we present data from a subset of pts with advanced epithelioid sarcoma. Pts were administered MAK683 120e300 mg twice daily (BID) or 500e800 mg once daily (QD) orally until unacceptable or dose-limiting toxicities (DLT) had developed, disease progression or death.Results: As of Jan 15, 2021, 14 pts with a median of 1.5 prior lines of therapy (range: 0e5) had been treated. Four (29%) were ongoing and 10 (71%) discontinued, primarily due to progressive disease (PD) (43%). Nine (64%) pts reported 1 treatmentrelated adverse event (TRAE) of any grade, with the most common (20%) being alopecia (36%), nausea, neutropenia, thrombocytopenia (29% each), and diarrhea (21%). Grade 3/4 TRAEs were reported in 50% pts, with 20% reporting neutropenia and thrombocytopenia (21% each). DLT were reported in 2 pts receiving 120 and 300 mg BID, respectively. There were no treatment-related deaths. Partial response was observed in 2 pts (14%) receiving 120 mg BID and 500 mg QD respectively. Six (43%) pts had stable disease and 3 (21%) had PD. The overall response rate was 14% (95% CI: 1.8e42.8) and the disease control rate was 57% (95% CI: 28.9e82.3). Duration of response of the two responders were 16.5+ and 5.2+ months.Conclusions: MAK683 was generally well-tolerated and there were preliminary signs of activity in pts with advanced epithelioid sarcoma.

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Purpose Human resource records are the cornerstone of human resource management. Organizations rely a great deal on their employees to furnish them with human resource records, which is crucial to the effective management of the employees and the success of the organization. It is evident, however, that personal information-related issues in organizations are of significant concern and that examining employees’ perceptions and attitudes regarding personal information management is extremely valuable. Yet, this is largely absent in the literature. This study, therefore, aims to investigate the influence of perceptions of employees concerning the uses and security of human resource records on their attitude toward human resource records in Ghana. Design/methodology/approach A descriptive survey design was used in this study. An online questionnaire was used to gather responses from employees for analyses. A structural equation model was developed and assessed because of the advantages that come with its use and the characteristics of this study. The assessment of the structural equation model was done to determine the significance of the hypothesized paths. In addition, effect size, coefficient of determination and predictive relevance of the structural model were assessed. Before that, the validity and reliability of the measurement model were examined through the assessment of the indicator loadings, average variance extracted, Cronbach’s alpha and composite reliability. An importance-performance map analysis (IPMA) was also conducted. Findings The hypotheses formulated in this study could not be rejected because the hypotheses tested were statistically significant. Thus, this study revealed that employees’ perception of the uses of human resource records influenced their attitude toward human resource records. Also, employees’ perception of the security of human resource records influenced their attitude toward human resource records. The IPMA revealed that the perception of uses of human resource records was more important, yet its performance was below the perception of security as significant. Practical implications Human resource records management professionals, particularly in Ghana, ought to ensure that the human resource records in their organizations are used for the purpose for which they are collected and also, secured. In addition, they should assure employees that their personal information is used as expected and secured. This could be realized with the use of international records management standards especially those in the ISO 30300 series. More so, human resource managers as part of their counseling duties also need to counsel employees so that they form positive perceptions about the uses and security of the personal information they give to their organization in the course of their employment. Originality/value To the best of the authors’ knowledge, this study brings to light the attitude of employees toward human resource records based on their perceptions of uses and security in the Ghanaian context which is absent in the literature as previous studies have focused mainly on personal information management behavior only at the individual level.