Spreading depolarizations is a generic term for the spectrum of waves initiated and propagated in the central nervous system (CNS), characterized by abrupt and near-complete sustained neuronal depolarization 1,4 , observed as a large slow potential change in the extracellular space 5,6 and propagate at 1-9.5 mm/min across the brain 7,8 . During SDs, neurons cannot fire action potentials, as the sustained depolarization is above the threshold, and the
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.