Plate IXThe following observations were made by us on a chimpanzee, Anthropopithecus troglodytes, at Freetown, Sierra Leone. The animal, according to the statement of the owner, had suffered from an attack of dysentery lasting from January ist to January i6th, 1922. It was examined by us on the iith and 12th of Januar\', at SUMMARY A parasite morphologically indistinguishable from P . falciparum was found by us occurring naturally in a chimpanzee in Freetown,West Africa. This parasite appears to be the same as that described by Reichenow in chimpanzees and gorillas, and stated by him to be the human parasite.Laboratory -bred A. costalis fed on this chimpanzee failed to become infected, but, as stated above, crescents were few and exflagellation was not observed.We have failed to transmit the infection to two human subjects by subcutaneous and intravenous inoculation.

PLATESXV-XVIII TABLE OF CONTENTS PAGE I. INTRODUCTION ... ae re He 405 = os "oe dee soe ee Aaa II. NOMENCLATURE Ae a aes a TT Yr a sae coe 1446 TI. GeroGrapuicat DisTRIBUTION eae se ae Ae ae Sais area 4 7 IV. MorpHoLtocy AND Bionomics-(ryiAXehalt it . 2 ae. ¥3 Sec ae oe +7 es 2 i. 9449 (2) Egg is ome 2 SA eee eee ee eee ge er ers (3) Larva-(ae weehistar 4202 BIBL? STON FE DA, 957 14 S79 (6) 2nd instar cas) Meceate. «9h meee oe ae > 2 Fy es tinh eaeh 9 409 (c) 3rd instar aes ose eae re ee we ms ee Aa (4) Puparium eee ee Sern eet | Sse ee ee AT V. DeveLOPMENT IN ANIMALS-(1) Duration in experiments Se See er on cted abies op een (2) Pathogenicity to animals =e es "yt rahe nie bee ATO (3) The animal hosts in nature... oe 3% = aii ak if: GEaSs (4) The main natural reservoir... ae ve ane ee Pee gh y-(5) Temperature of animal host and rection ow Ie ook ask 2 dod (6) Puparia in nature ot an 8 & 7m Bie 32 HICSS VI. Ace INcIDENCE ask aoe. BAF aoe er as bed oe See vA. O0 VII. Immunity pias +e ? "ap 5ee Bas ae i Sey ack AOD VIII. Srasonat INCIDENCE ... eee wee ane are tr ae

Uveal cysts in domestic cats are rare ophthalmic findings, and in most cases, they do not cause any clinical problems The Burmese breed is overrepresented in the data, with a relatively high prevalence of uveal cysts.

Melanocytic neoplasia is the most common form of ocular tumour in cats, accounting for 67% of cases in an analysis of 2614 cases of primary ocular neoplasia. Feline diffuse iris melanoma (FDIM) is by far the most common form of ocular melanocytic neoplasia, with limbal melanomas and atypical melanoma (melanoma affecting the choroid or ciliary body) infrequently recognised. Early lesions begin as flat areas of pigmentation of the iris, known as iris melanosis. This melanosis is a precursor lesion that can become FDIM when pigmented cells infiltrate the anterior iris stroma, commonly alongside a transition in cell morphology. The differentiation between FDIM and benign iris melanosis is only recognisable though histologic examination, with no in vivo means of identifying the malignant transformation. The behaviour of FDIM is variable and difficult to predict. Some FDIM lesions have a more benign progression and can slowly grow or remain static for years without affecting the ocular or systemic health of the individual, whilst other tumours behave aggressively, invading the ocular structures and significantly affecting the life expectancy of cats through metastatic disease. This makes management and timely enucleation of these cases challenging in practice. This article aims to review our current knowledge of FDIM.

During the months of July, August and September, 1924, the examination of twenty-six placentas for malaria parasites was carried out among native women in Freetown. EXAMINATION OF THE PLACENTAThe placenta arrived at the Laboratory at variable periods after delivery, sometimes within an hour and almost always within twelve hours. An incision was made through a cauterized area on the placenta, blood was withdrawn from the bottom of the cut by means of a pipette, films were spread, and stained either with Leishman's or Giemsa's stain. Malaria parasites were found in twelve, i.e., 46 per cent of the twenty-six cases. EXAMINATION OF MATERNAL PERIPHERAL BLOODThe maternal peripheral blood was examined at the time of the birth in twenty-three of these cases, with the result that only four, 1.e., I7 per cent. were found positive. No case of infection of the maternal peripheral blood was found in which the placental blood failed to show a much heavier infection.Among the twenty-six cases there were four accidents (premature birth, ete.). In the twenty-two cases which had normal labour there were nine, 1.e., 41 per cent., in which the placental blood showed parasites, whereas in the four cases which had abnormal labours there were three, i,e., 75 per cent., in which the placenta showed parasites, RY .