Since, however, albumin and globulin values obtained by electrophoresis are likely to become more widely used in clinical work, and since Majoor's method gives results said to be closer to those of electrophoresis than Howe's method, this alone would seem to be a good reason for employing Majoor's. Summary Howe's (using 22% sodium sulphate concentration) and Majoor's (using 26%/ sodium sulphate concentration) methods for differential plasma protein estimation were compared by means of parallel assays on a series of normal and pathological plasnmas.We found that there is little advantage in one method over the other, because the reproducibility of results is identical, the normal ranges are equal, and the separation of results into diagnostic patterns is only slightly better when Majcor's method is used. The arithmetic difference between the two albumin levels is relatively constant in the conditions studied, and therefore either albumin level is reasonably predictable from the other.Since Majoor's method is said to give results closer to those of electrophoresis than Howe's, this, together with the slight advantage indicated by our own results, would seem to be a good reason for employing Majoor's method.