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Interleukin (IL) 1α induced the up-regulation of cell-surface-expressed epidermal growth factor (EGF) receptor on both MDA-MB-468 and BT-20 breast cancer cell lines. IL-1β and tumor necrosis factor α (TNF-α) increased the EGF receptor surface expression only on BT-20 breast carcinoma cells. 12-0-tetradecanoylphorbol 13-acetate (TPA) induced up-regulation of EGF receptor on MDA-MB-468 cells, and a marginal but significant increase was determined in BT-20 cells and in interferon γ (IFN-γ)-treated MDA-MB-468 cells. CD15 (Lewis^x) antigen was down-regulated on MDA-MB-468 cells by TNF-α, TPA, IL-1α, as well as by IFN-γ and all-trans-retinoic acid. 1,25(OH)₂-vitamin D₃ up-regulated the CD15 antigen surface expression on MDA-MB-468 cells.

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