Purpose: to describe a clinical case of successful application of photodynamic therapy (PDT) in a patient with leukoplakia of the glans penis skin.Material and methods. For PDT, chlorin-type photosensitizer “Photolon” was used. The photosensitizer (lyophilized powder) was diluted in 200.0 ml of 0.9 % sodium chloride solution, administered intravenously at dosage 1.5 mg/kg of body weight. After 2.5 hours, intravenous laser blood irradiation was performed with “Lakhta-Milon” laser device (output power – 100 mW, exposure – 30 minutes). Before PDT, fluorescence diagnostics in ultraviolet light with wavelength 395–405 nm was performed. PDT technique was single-field irradiation with output power 1800 mW (1.8 W), irradiation energy density – 150 J/cm2. Power density of laser light was 200 mW/cm2. Exposure time – 14 min.Results. After treatment, complete regression of the pathological focus and regeneration of healthy tissue were marked (one month).Conclusion. PDT in a patient with leukoplakia of glans penis is an effective and safe curative technique.