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The effect of lipophilic [N (3,5 di tert butyl 4 hydroxybenzyl) N,N di(2 pyridylmethyl)] amine and its water soluble hydrochloride on the oxidative status of tissues of Wistar rats in vivo was studied. The change in the xanthine oxidase activity, the level of free radical processes in blood, and the antioxidant activities of blood serum were determined by spectrophometry. The contents of TBA dependent products (TBA is thiobarbituric acid) in animal tissues were mea sured by biochemiluminescence under induced oxidative stress conditions. The effect of [N (3,5 di tert butyl 4 hydroxybenzyl) N,N di (2 pyridylmethyl)]amine on organism in vivo is multi factorial and is more pronounced for the water soluble hydrochloride.

Introduction. The article includes a comparative study of phenotypic manifestations of undifferentiated connective tissue dysplasia in children of different age groups with urological and andrological pathology. Material and methods. The trial performed included 214 children aged from 1 month to 17 years with clinical manifestations of undifferentiated connective tissue dysplasia who were treated in the children’s uroandrological department for congenital malformations of the urogenital system. The generally accepted table of external phenotypic markers in scores was used in establishing undifferentiated connective tissue dysplasia . Results. In infants, the most frequent disorders were in ears and skin. In the preschool age, in the majority of cases, craniocephalic abnormalities, pathology of osteo-articular system and ears were met. The trail has revealed that the rate of ocular abnormalities increases with age. Moreover, two or more ocular problems were most common in older children. Anomalies of the oral cavity were diagnosed only in a quarter of infants and were manifested in them by a single sign. In older age groups, oral cavity anomalies were in more than half of the patients, and often they were not isolated. During the survey of senior schoolchildren, it was noted that all children of this age group had this or that disorder in their osteo-articular system, and almost always they were multiple. Conclusion. Somatic manifestations of undifferentiated connective tissue dysplasia are often multiorganic and often have non-specific clinical symptoms. Identification of patterns of formation of uroandrological pathology in patients of different age groups with connective tissue insufficiency will ensure timely prevention and correction of visceral manifestations of dysplasia in children.

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