In a field trail at Wadi Sudr Research Station (Desert Research Centre) South Sinai in season (2006)(2007), the effect of nitrogen, potassium and sulfur on wheat yield, nutrients content and uptake. Three levels of N: 60, 90 and 120 kg/fed, five levels of K: 0, 50 and 100 kg K2O/fed were added to soil in one dose totally with the first nitrogen dose and the same rates 50, 100 kg K2O/fed but were divided into two equal doses (25+25), (50+50) and were added to soil at the same time of adding N fertilizer and two concentration, (1.5% and 3%) of K2SO4 (50% K2O) as a foliar application and two levels of S: zero (without) and one ton/fed.The results revealed that the yield of wheat, mineral content, and uptake were significantly increased as affected by NKS fertilization. Combination of N, K and S proved most effective with optimum yield of treatment 90 N, 100 K2O and with sulfur (one ton/fed).