The treatment of primary vitreoretinal lymphoma (PVRL) remains controversial regarding the use of local, systemic, or combined treatments. The aim of this study was to analyze the efficacy and toxicity of intravenous high‐dose methotrexate (IV HD‐MTX) based systemic therapy in a uniformly treated population of PVRL patients. From a nationwide French database, we retrospectively selected 59 patients (median age: 70 years, median Karnofsky Performance Status: 90%) with isolated PVRL at diagnosis who received first‐line treatment with HD‐MTX between 2011 and 2018. 8/59 patients also received a local treatment. No deaths or premature discontinuations of MTX due to toxicity were reported. A complete response was obtained in 40/57 patients after chemotherapy. Before treatment, IL‐10 was elevated in the aqueous humor (AH) or in the vitreous in 89% of patients. After treatment, AH IL‐10 was undetectable in 87% of patients with a CR/uCR/PR and detectable in 92% of patients with PD/SD. After a median follow‐up of 61 months, 42/59 (71%) patients had relapsed, including 29 isolated ocular relapses as the first relapse and a total of 22 brain relapses. The median overall survival, progression‐free survival, ocular‐free survival and brain‐free survival were 75, 18, 29 and 73 months, respectively. IV HD‐MTX based systemic therapy as a first‐line treatment for isolated PVRL is feasible, with acceptable toxicity, even in an elderly population. This strategy seems efficient to prevent brain relapse with prolonged overall survival. However, the ocular relapse rate remains high. New approaches are needed to improve local control of this disease, and ocular assessment could be completed by monitoring AH IL‐10.

It is well known that linear rank-metric codes give rise to q-polymatroids. Analogously to classical matroid theory one may ask whether a given q-polymatroid is representable by a rank-metric code. We provide a partial answer by presenting examples of q-matroids that are not representable by F q m -linear rank-metric codes. We then go on and introduce deletion and contraction for q-polymatroids and show that they are mutually dual and that they correspond to puncturing and shortening of rank-metric codes. Finally, we introduce a closure operator along with the notion of flats and show that the generalized rank weights of a rank-metric code are fully determined by the flats of the associated q-polymatroid.

PresbyPRK and presbyLASIK are comparable in efficacy, stability, predictability, and safety at 12 months postoperatively. PresbyPRK is a good alternative when presbyLASIK is contraindicated.

q-Matroids form the q-analogue of classical matroids. In this paper we introduce various types of maps between q-matroids. These maps are not necessarily linear, but they must map subspaces to subspaces and respect the q-matroid structure in certain ways. The various types of maps give rise to different categories of q-matroids. We show that only one of these categories possesses a coproduct. This is the category where the morphisms are linear weak maps, that is, the rank of the image of any subspace is not larger than the rank of the subspace itself. The coproduct in this category is the very recently introduced direct sum of q-matroids.

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