CD10 is useful for distinguishing between BCC with widespread follicular differentiation and trichoblastomas.

No abstract

Immunologic methods to detect specific antibodies against Anisakis should be used routinely before diagnosing EG as primary disorder. Preventive measures are of capital importance.

The bcl-2 gene encodes a protein which inhibits programmed cell death (apoptosis). This protein was detected by immunohistochemical techniques in 48% of invasive ductal carcinomas of the breast. It was present in well-differentiated carcinomas with hormonal receptors, and proteins synthesized under the control of oestrogens: pS2, cathepsin D and ERD5. In contrast, bcl-2+ carcinomas are less frequently positive for p53 and have a Ki67 score under the mean. bcl-2 protects cells against apoptosis. Accumulation of p53 protein, which is indicative of p53 mutation, would have the same effect; however, these two proteins seem inversely related, an inverse correlation observed by others in breast cancer cell lines and in lymphomas. Tumours positive for bcl-2 escape apoptosis and have worse prognosis but this is not what is found; survival at 5 years, and particularly the absence of recurrence during the first 5 years after surgery, seem to be associated with bcl-2 positivity. The bcl-2 protein seems only to be an important prognostic factor in women over 54 years of age. Moreover, p53-bcl-2+ tumours have a better response to hormonal therapy than p53-bcl-2-tumours.

No abstract