Background and Purpose of Study: our study aims to determine whether the use of Lipofilling (LPF) after conservative surgery (CS) of invasive breast cancer (BC) is a possible risk factor in the local recurrence of this tumor. As secondary objectives, we will assess patient satisfaction after LPF and the percentage of patients with post-operative asymmetries.Material and Methods: we carried out a retrospective, case-control study. We selected patients who, between 2010 and 2014, had undergone CS of Invasive BC, and were subsequently treated with LPF (using the Coleman technique) and controls had undergone CS of BC without later use of LPF. The minimum follow-up time was 5 years. Results:No local recurrence was observed in the controls, but in the cases, 4 local recurrences were observed. This implies an incidence of 20 % in CS after LPF, a statistically significant difference with a p-value of 0.0036. The influence on recurrence of tumor size variables, vascular involvement, duration of hormone therapy and use of chemotherapy has been analyzed, without finding any statistically significant differences between cases and controls. No influence has been observed on the time elapsed from the date when CS and the first LPF and the volume of fat transferred with the risk of local recurrence. Likewise, 50 % of patients are satisfied with LPF reconstruction and 20 % have presented asymmetries later. Conclusion:LPF may be a risk factor in local recurrence of invasive breast cancer after CS.