The oxidation of 14C-labelled compounds has been studied by administering these compounds to animals and subsequently collecting and analysing their expired CO2 for radioactivity. When an attempt is made to relate the appearance of radioactivity in the expired breath with the rate of oxidation of the specific labelled compound, several difficulties arise in the interpretation of the patterns of 14CO2 excretion. This is due to the multiplicity of metabolic events concerned in the conversion of a metabolite to C02, and in the subsequent transport and elimination of this CO2 from the body.

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