The increase in MVD and MCD reveals their role in the pathogenesis of OSMF, a lesion characterized by progressive fibrosis in early stages and failure of degradation or remodeling in the advanced stages.

Fixation is an initial and important step in tissue processing for microscopical examination. The primary aim of fixation is to preserve the tissues in a life-like state, prevent bacterial putrefaction, prevent autolysis, and increase the refractive index of the tissue. The present study used a natural fixative instead of chemicals in order to prevent the deleterious effects of the chemical fixatives. The aim of this study was to determine the effectiveness of honey as a fixative, which is a natural product. A double-blind pilot study was conducted in the Department of Oral and Maxillofacial Pathology with the consent of patients who were visiting the hospital for other dental problems. A total of 30 specimens were taken, fixed using formalin and honey for 24 hours and then subjected to routine processing. The tissues were then stained with hematoxylin and eosin and were subjected to evaluation. Student's t-test was performed and analysis was done using Statistical Package for Social Science version 17 software. The numerical scores were graded from 1 to 4 and the mean standard deviation was calculated. The results showed statistically significant differences between honey and formalin samples for both nuclear details and cytoplasmic staining. Honey, as a tissue fixative, is easily available with no known toxicity and can be used as an alternative to formalin. However, studies should be done further to find methods to eliminate the disadvantages, such as homogenization, seen with the connective tissue. Furthermore, studies with large sample sizes are required to obtain more conclusive results.

Objective:Giant cell fibromas (GCF) of the oral cavity are found predominantly in Caucasians and rarely in other races. This retrospective study was done to evaluate the clinicopathological features of GCFs in a sample of Indian population.Materials and Methods:21 oral GCF cases were investigated from the year 1995 to 2010. Clinical data and microscopic features were reviewed and analyzed.Results:The mean age of patients at the time of diagnosis was 39years. Oral GCF occurred in patients between 6 and 67 years of age. The lesions were 4-17 mm in greatest dimension. GCF frequently has the provisional diagnosis of fibroma or papilloma. All tumors were treated by total surgical excision and no recurrence was reported. The consistent and diagnostic feature was the presence of large stellate giant cells, usually with one or two nuclei. Multinucleated giant cells were seen occasionally. These giant cells were most numerous in the connective tissue beneath the epithelium.Conclusion:Though there are distinct histopathologic features for GCF, its clinical presentation and prognosis are similar to the conventional fibroma/fibroepithelial polyp.

Background:The “gender determination” which is an important human identification procedure not only helps in establishing the biological profile from skeletal and dental remains but also in facial reconstruction of unidentified victims.Aim:The aim of this study is to analyze predominant types of lip prints (cheiloscopy), accuracy of mandibular canine index (MCI) (odontometric), and facial index in the study population and to identify whether any correlation among the above parameters could help forensic dentistry in solving crimes.Materials and Methods:A pilot study was conducted in 100 individuals, 50 males and 50 females aged between 20 and 25 years. For each individual, the lip prints, MCI, and facial index measurements were recorded on the same day analyzed by two observers. All the analysis was done using SPSS version 14 assessed using t-test and Chi-square test.Results:Type II pattern of lip prints is observed as common pattern among male and female. There is no significant difference in Odontometric analysis. The mean value of facial index analysis in both genders shows highly significant.Conclusion:A large-scale study is required in order to validate our results to arrive at definitive results and value.

Ultrasonography is a non-invasive diagnostic tool for OSMF. It could be a better diagnostic tool compared to clinical and histopathological examination.