Securinega virosa (S. virosa) is a commonly used psychiatric illnesses. Thus, the current study aimed at methanol extract of S. virosa in mice. determined. The antidepressant activity of the extract (500, 250 and 125 mg/kg) using the tail suspension test(TST), forced swim test (FST) and open field test (OFT).The median lethal dose was estimated to be flavonoids, alkaloids and cardiac glycosides were found to be present in the crude extract. The methanol root bark extract of S. virosa significantly (p<0.05) decreased duration of immobility and also decreased comotion and explorator showed that the root bark extract of S. virosa