A field experiment was conducted at the college of Agriculture – university of Anbar during the winter season of 2018-2019 using complete randomized blocks design (RCBD) to investigate effects of bio-fertilizer (BF) and different rates of mineral fertilizers (MF) from fertilizer recommendation (FR) on the growth and yield of wheat (IBAA cultivar). The growth and yield traits consisted of plant height (PLH), number of tillers (NT), number of spike (NS), number of grains per spike (NGPS), weight of 1000 grains (WG), biological yield (BY), and grains yield (GY). Treatments consisted of: control T0 (without BF and MF); BF (T1); 100% of FR (T2); BF+25% of FR (T3); BF+50%FR (T4); BF+100% FR (T5). Results indicated that the treatment of adding biological fertilizer with 100% mineral fertilizer(T5) was superior in most of the studied characteristics except for the total number of organisms in the soil. The fertilization treatment (T4) did not differ significantly from treatment (T5) in most of the characteristics included in the study except that increasing of microorganisms in the soil. Thus, 50% of the mineral fertilizer can be substituted with the biological fertilizer to reduce the risk of contamination and reduce the cost of mineral fertilizer.