In studies dealing with the production of antibody in mice, it has been found feasible to incorporate the antigen in Freund’s adjuvant in order to stimulate a response with a single injection of antigen [8]. In the course of such a study a number of interesting hematological changes have been noted. The present study describes such alterations in the peripheral blood leucocyte pattern, following immunization with BSA in complete Freund’s adjuvant, which are of especial interest because of similarities to the hematological picture observed in neonatally thymectomized mice [9, 10, 7]. Coterminus changes in thymus and spleen weights are described, and the role of adjuvant in inducing these phenomena is discussed.

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