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A simple, accurate, precise method was developed for the simultaneous estimation of Dapagliflozin and Saxagliptin in Tablet dosage form. Chromatogram was run through Standard BDS C8 column (50 × 4.6 mm, 5) The Mobile phase containing Potassium dihydrogen phosphate: Acetonitrile in the ratio 55:45, pH was adjusted to 3.8 with dilute orthophosphoric acid. The solution was pumped through the column at a flow rate of 1 ml/min. The column temperature was maintained at 30°C. Optimized wavelength selected was 210 nm. Retention time of Dapagliflozin and Saxagliptin were found to be 2.266 min and 2.805 min. % RSD of the Dapagliflozin and Saxagliptin were found to be 0.5 and 0.5 respectively. % Recovery was obtained as 98.98% and 98.72% for Dapagliflozin and Saxagliptin respectively. LOD, LOQ values obtained from regression equations of Dapagliflozin and Saxagliptin were 0.20, 0.60 and 0.26, 0.79 respectively. Regression equation of Dapagliflozin is y = 37377x + 89244, and y =12254x + 3122 of Saxagliptin. The retention times were decreased so that the run time also decreased. So the method developed was simple and economical that can be applied successfully for simultaneous estimation of both Dapagliflozin and Saxagliptin in bulk and combined tablet formulation.

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The aim of study was to synthesize a new series of thiazolidinedione's. Thiazolidinedione's or glitziness forms a significant class of drugs which exhibit biological activities ranging from antidiabetic, anti-inflammatory, antibacterial, antifungal, antiviral and anticancer. In the present study reported a systematic synthesis of thiazolidinedione analogues. A new series of 2, 4-thiazolidinedione based derivatives have been synthesized by the condensation of various substituted phenoxy benzene amines and 4'-chlorosulphonyl 5-benzylidene-2, 4-thiazolidinedione. The structure of these compounds were established by IR and 1 H NMR. These new compounds (F1-F7) were evaluated for their antidiabetic activity on albino rats. Most of the compounds showed significant antidiabetic activity when compared with the standard drug metformin.