Objective: To evaluate the protective effect of PHF, a polyherbal formulation, against two experimentally induced hepatotoxicity models in rats. : Hepatoprotective activity of the PHF containing two Materials and methods indigenous medicinal plants extracts and , was screened against CCl and Tinospora cordifolia Curculigo orchioides 4 paracetamol induced hepatotoxicity in rats. : Administration of hepatotoxins (CCl and paracetamol) shows Results 4 significant morphological, biochemical and histopathological deteriorations in the liver of experimental animals. Pretreatment with PHF had significant protection against hepatic damage by maintaining the morphological parameters within normal range and normalizing the elevated levels of biochemical parameters (SGPT, SGOT, ALP and total bilirubin), which were evidently showed in histopathological study. The PHF has highly Conclusions: significant hepatoprotective effect at 200 and 400 mg/kg, p.o. on the liver of all the two experimental animal models. The liver protection due to combined action of all plant extracts along with their phytoconstituents.