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The morphology of the neoplastic cells was studied in four cases of leukaemic reticuloendotheliosis (LRE). Aspirated material from the spleen and liver was found to be rich in cells with the characteristic morphology and this may be of value for the diagnosis since leukopenia is common and bone marrow may be hard to obtain in LRE. No phagocytic activity could be demonstrated in the leukaemic cells. The incorporation of tritiated thymidine into the cells was extremely low, indicating a low proliferative capacity of the neoplastic tissue. It is suggested that the richness in neoplastic, lymphoid reticulum cells in blood, bone marrow, spleen and liver is due to an accumulation of cells with a low rate of proliferation.