This research was aimed at establishing high-quality and abundant cocoon cultivation in the country, to create new high-quality and nutritious mulberry varieties and gradually introduce them into production. In order to create local mulberry varieties, for the first time the viability of mulberry silkworm hybrids of mulberry varieties “Jararik-9”, “Jararik-10” was determined by the level of cocoon productivity and technological impact. The coefficient of leaves eating of new varieties of mulberry “Jararik-9”, “Jararik-10” by hybrid worms of silkworm was determined. The varieties of mulberry belonging to the genus Morus alba L. and hybrids belonging to the genus Bombyx mori L of the mulberry silkworm were taken as the study objects. For chemical analysis, leaf samples were taken and analyzed in the spring in the order established by the worms in the middle of the 5th year of development. Furthermore, the effect of new mulberry varieties on the growth dynamics of worm leaves was studied. The coefficient of leaves eating of new mulberry varieties by hybrid worms was determined. According to the results of the research, among the new selection numbers No3-02 and No7-02, the coefficient of assimilation of No3-02 and No7-02 is significantly higher than other selection numbers and “Tajik seedless” variety.