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Laboratory studies of collagen-based compositions demonstrated digispon to be the most effective agent for clinical use. Digispon is permeable to vapor and air, plastic, ensures prolonged dosed release of dioxydine into the wound, stimulates the growth of granulation tissue, accelerates marginal and islet epithelialization, and reduces the likelihood of the formation of coarse scar tissue. Radioautographic study of wound granulation tissue in experimental animals with modeled nonsuppurative inflammation showed that the principal processes ensuring wound healing during the application of collagen-based agents occur in the early stages, with an increase in the number of fibroblasts, including the proliferating variety, and blood vessels.

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We carried out an electron microscopic study of solid pseudopapillary tumors of the pancreas (operation material) from 15 patients. Two cell types were distinguished. Type 1 cells had large oval nuclei, little changed mitochondria, and short fragments of the granular cytoplasmic reticulum. These cells formed mainly pseudopapillary structures around the vessels. Type 2 cells were characterized by pronounced nuclear polymorphism with specific "coffee bean" picture. The cytoplasm of these cells contained many large mitochondria with clarified matrix and often destroyed cristae; lipofuchsin granules were seen. The ultrastructural characteristics of the solid pseudopapillary tumor cells attest to their epithelial origin.