Effect of thermal cycling on high temperature creep of thin-walled and coated CMSX-4 single crystal superalloy was evaluated by performing thermal cycling and isothermal creep tests at 1050°C and 140 MPa, 1150°C and 140 MPa and 1150°C and 80 MPa. The deleterious effect of thermal cycling on the creep behavior and lifetime has been confirmed, particularly for the condition at 1150°C and 80 MPa. Furthermore, the number of low temperature incursions has severe detrimental effect on creep resistance on account of the rafted microstructure destabilization induced by these sequences. These results confirm the role of re-precipitation and dissolution of γ' particles during thermal cycling creep. Thermal cycling infers also on destabilization of subcoating zone in the superalloy but this effect seems to be secondary.