Objectives Pre-eclampsia (PE) 4.4 (95% CI,). Moreover, in the formerly pre-eclamptic group, prehypertension was associated significantly with 4.3 (95% CI,

Aerobic capacity and also proximal muscle strength were significantly impaired in our sample of children and adolescents with MCTD. Because respiratory problems were non-dominant in our patient group, the decreased aerobic capacity and muscle strength were probably caused by musculoskeletal impairments. Further studies in larger multicentre samples are warranted to confirm our findings.

To study the impact of musculoskeletal and cardiorespiratory impairment on the exercise capacity in children with mixed connective tissue disease (MCTD). Frequently reported clinical symptoms include arthritis, myositis, fatigue and cardiorespiratory impairment. However, the exercise capacity of patients with MCTD has not been studied systematically before.