We describe a case of a healthy 61-year-old man who developed disseminated intravascular coagulation and venous thromboembolism secondary to acute Epstein-Barr virus (EBV) infection. The EBV was confirmed via serology and polymerase chain reaction. Although more common in children and young adults, acute EBV infection may also occur in middle-age and older adults and should be considered as a differential diagnosis in every patient presenting with disseminated intravascular coagulation.

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