Osteoarthritis is most widespread form of arthritis seen in elderly and knee joint pain is the most common complaint for which medical advice is sought in such circumstances. Major treatment for this complaint is prescription of established calcium compounds with NSAID's. But with this established treatment also total eradication of the pain is not possible. Basti (a medicated enema) in Ayurveda is practiced in many connective tissue disorders like Rheumatoid Arthritis, Osteoarthritis, Gout, Lumbar Sprain, Spondylosis etc. The present study was conducted at L.K.Redekar Ayurveda College and PG Research Centre Gadhinglaj Dist Kolhapur, India, with the aim and objective of assessing efficacy and safety of Guggulutiktaka ghrita in the management Knee Osteoarthritis. It's found that there is incredible role of guggulutiktaka ghrita in the management of sandhigatavata vis as vis Osteoarthritis