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The aim of this article was to study a case report of full mouth rehabilitation in a severally periodontally compromised patient in which 18 single piece basal implants were inserted and functionally loaded with both maxillary and mandibular cement retained fixed partial denture. Basal implants were loaded immediately, and excellent results were obtained. Bone loss was measured and values were recorded immediately after implant placement and after 6 months. Basal implants are used to support single and multiple unit restorations in the upper and lower jaws. They can be placed in the extraction sockets and also in the healed bone. Their structural characteristics allow placement in the bone that is deficient in height and width. Basal implants are the devices of the first choice, whenever (unpredictable) augmentations are part of an alternative treatment plan. The technique of basal implantology solves all problems connected with conventional (crestal) implantology.

Type 2 diabetes mellitus (T2DM) is a polygenic metabolic disease described by hyperglycemia, which is caused by insulin resistance or reduced insulin secretion. The interaction between various genetic variants and environmental factors triggers T2DM. The aim of this study was to find risk associated with genetic variants rs5210 and rs2237895 of KCNJ11 and KCNQ1 genes, respectively, in the development of T2DM in the Indian population. A total number of 300 cases of T2DM and 100 control samples were studied to find the polymorphism in KCNJ11 and KCNQ1 through PCR-RFLP. The genotype and allele frequencies in T2DM cases were significantly different compared to the control population. KCNJ11 rs5210 and KCNQ1 rs2237895 variants were found to be significantly associated with risk of T2DM in dominant (KCNJ11: OR, 2.07; 95% CI, 1.30–3.27; p−0.001; KCNQ1: OR, 2.33; 95% CI, 1.46–3.70; p−0.0003) and codominant models (KCNJ11: OR, 1.76; 95% CI, 1.09–2.84; p−0.020; KCNQ1: OR, 1.85; 95% CI, 1.16–2.95; p−0.009). We also compared clinicopathological characteristics between cases and control and observed a significant difference in all the parameters except HDL, gender, and family history. In this study, clinicopathological data with a carrier of a variant allele of both KCNJ11 and KCNQ1 genes were also analysed, and a significant association was found between the carrier of a variant allele with gender and PPG in KCNJ11 and with triglyceride in KCNQ1. We confirm the significant association of KCNJ11 (rs5210) and KCNQ1 (rs2237895) gene polymorphism with T2DM, indicating the role of these variants in developing risk for T2DM in Indian population.

To evaluate the feasibility and effect on marginal adaptation in class II composite restoration reinforced with polyethylene fibres in teeth with affected dentine using scanning electron microscopy. Method and material: Class II cavities with dimension 1.5 +0 .25 pulpal depth and 4 ± 0.25 mm buccolingual width/.were prepared on proximal surfaces extracted human molars or premolar with affected/sound dentine on gingival margin. The etching priming and restorations were done in prepared samples as per manufacture directions. The samples were divided in 2 groups depending on use of ribbond inserts in composite restorative material. Samples were finished, stored in distilled water and then thermocycled manually and then sectioned longitudinally through the restorations. The marginal adaptation was evaluated using scanning electron microscope (SEM). Result: The result showed that there was a definite gap all along the interface between caries affected dentine and the composite material in both the groups. The bigger gap was present in group II compared to group I.

Introduction Obesity plays a pivotal role in the development of metabolic syndrome—excessive body fat, spikes in blood glucose levels and hypertension—and ultimately leads to cardiovascular diseases and type 2 diabetes (T2D), if left unattended. The present study aimed to investigate the associated risk of T2D with obesity risk alleles of fat mass and obesity-associated (FTO) and melanocortin 4 receptor (MC4R) genes. Methods The study includes 400 subjects (300 T2D diabetic cases and 100 healthy controls). Genetic analysis was done by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) methods. Results The findings of the study show no significant increase in odds of diabetes associated with the prevalence of FTO and MC4R minor alleles. Rare allele frequencies for “A” of FTO rs9939609 were 0.34 and 0.30 in cases and controls, respectively. Rare allele frequencies for A of MC4R rs12970134 were found to be more common in controls (0.45) than cases (0.41), but the difference was insignificant ( p 0.246); however, an increase in body weight with the presence of allele “A” of the FTO gene ( p value < 0.001) was found, indicating indirect involvement in the development of T2D. In addition, these were also correlated with the demographic/lifestyle and clinico-pathological parameters between T2D cases and controls. We found that T2D patients with a history of smoking and high consumption of alcohol, fast foods and sweetened beverages are at high risk of T2D compared to healthy controls ( p < 0.01*). Conclusion The present study concludes that there is no direct association of rs9939609 of the FTO gene with the occurrence of diabetes in the Indian population, but its role in T2D development cannot be overlooked altogether. Furthermore, we conclude that the rs9939609 of FTO carries a potential risk of obesity and because of this FTO rs9939609 T > A is widely considered an obesity-associated allele/single-nucleotide polymorphism (SNP).