Cataract is one of the chief causes of blindness and visual impairment in the elderly people throughout the developing world. The aim of the study was to investigate the possible protective role of oral bupropion against selenite induced cataract in rabbits. Adult rabbits were used in the present study. Groups of study were: Apparently normal group, Cataract group and oral bupropion group. Cataract induction was done by a single intravitreal injection of 0.1 ml (0.01% w/v) of sodium selenite solution in the right eyes. Bupropion (50 mg/kg two times daily) was given for five days before intravitreal injection sodium selenite solution and 21 days after. The parameters were: Lens opacity, pupil diameter, light reflex, corneal sensation, conjunctival redness, the level of malondialdehyde (MDA) and reduced glutathione (GSH) in aqueous humor of rabbit eyes. Oral bupropion resulted in high significant protection from cataract development and there was no change in pupil diameter, positive light reflex, positive corneal sensation, no conjunctival redness, decreased level of MDA and increased level of GSH.