Stroke merupakan penyakit penyebab kematian terbanyak kedua didunia dan peringkat ketiga terbanyak sebagai penyebab kecacatan. Stroke tidak hanya berdampak pada bidang kesehatan, tetapi dapat mempengaruhi bidang sosial, fisik, dan psikologis karena penurunan kualitas hidup penderita dan bidang ekonomi karena memerlukan biaya yang besar dalam perawatannya.  Hingga saat ini penanganan stroke masih terpusat dalam pengobatan dan rehabilitasi, diperlukan upaya promotif dan preventif dalam penanganan stroke. Beberapa studi menunjukkan bahwa terdapat hubungan antara mikrobiota usus dan sistem saraf yang disebut Gut-Brain Connection atau Gut-brain Axis (GBA). Mikrobiota usus memiliki peranan penting dalam GBA. Menjaga keseimbangan mikrobiota usus merupakan salah satu cara dalam mencegah terjadinya stroke, melalui komunikasi dua arah baik secara neuronal atau non-neuronal yang terjadi antara otak dan usus.

Stroke is the second most prevalent cause of death in the world and placed third in disability causes worldwide. Beside affecting health, the reduced quality of life and the expensive cost of its treatment also has a huge impact on social, physical, and psychological aspect of a patient. Currently, the management of stroke is centered on currative and rehabilitative effort. Hence, the preventive efforts are on demand. Several studies have showed that there is a link between gut microbiota and the nervous system in somehing called the Gut-Brain Axis (GBA). Intestinal microbiota plays an important role in GBA. Therefore, maintaining the balance of intestinal microbiota, through neuronal or non-neuronal two-way communication between both of those system, is a promising way to prevent stroke. The writing of this article includes various sources originating from scientific journals and government guidelines and related agencies. Source searches were carried out on online portals for journal publications such as Google Scholar (scholar.google.com) and the National Centre for Biotechnology Information/NCBI (ncbi.nlm.nih.gov), with the keyword “Gut Brain Connection”