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Two novel cobalt(III) pyridine complexes (1) [Co(en)2(py)2]3+ and (2) [Co(en)2(mepy)2]3+ (en=ethylenediamine, py=pyridine, and mepy=methylpyridine) have been synthesized and characterized. The interaction of these complexes with calf thymus DNA was investigated by absorption, emission spectroscopy, viscosity measurements, DNA melting, and DNA photocleavage. Results suggest that the two complexes bind to DNA via groove mode and complex 2 binds more strongly to CT DNA than complex 1. Moreover, these Co(III) complexes have been found to promote the photocleavage of plasmid DNA pBR322 under irradiation at 365 nm, cytotoxicity results of complexes are also showing anticancer activity.

요약. L이 urea, acetamide, semicrabazide, formamide 인 thiocyanato (L) Cobaloxime 착물을 합성하고 특성을 규명하였다. 주제어: Thiocyanato 리간드 cobaloximes, Thiocyanato 로 연결된 dicobaloximes, 항균 활성, DNA 결합 Thiocyanato(L)cobaloximes (SCNCo(DH)2(L))과 benzyl (aquo) cobaloxime PhCH2Co(DH)2(OH2)를 반응시켜 일반 분자식 ABSTRACT.Complexes of thiocyanato(L)cobaloximes where L is urea, acetamide, semicrabazide and formamide were synthesized and characterized. The reaction of thiocyanato (L) cobaloximes (SCNCo(DH)2(L)) with benzyl (aquo) cobaloxime PhCH2Co (DH)2(OH2) was found to produce a series of thiocyanato bridged dicobaloximes of a general formula of PhCH2Co(DH)2SCNCo (DH2)(L). Evidence for formulation as dicobaloximes containing thiocyanato ligand bridges was obtained from infrared data which show 20 -45 cm -1 increase in νCN upon formation of the dicobaloxime from the corresponding terminal thiocyanocobaloxime (SCNCo(DH)2(L)). Further characterization of these two series was done on the basis of ( 1 H, 13 C)NMR, LCMS and elemental analysis. Anti-microbial activity of thiocyanato(L)cobaloximes and thiocyanato bridged dicobaloximes were screened against E. Coli. The DNA-binding behaviors of both monomers and dimers were investigated by spectroscopic methods and viscosity measurements. The results indicated that the dimer complexes bind with calf-thymus DNA in an intercalative mode via the terminal benzyl ring into the base pairs of DNA. It was observed that the monomer complexes did not interact with DNA. Fluorescence spectra for the interaction between thiocyanato bridged dicobaloximes and DNA were also studied.

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