Key Clinical Message Due to overlapping clinical symptoms, it may be difficult to distinguish between Hodgkin lymphoma and tuberculosis. Repeated investigations, especially biopsy and histopathological examination, may be helpful to establish a correct diagnosis. Herein, we present a case of Hodgkin's lymphoma misdiagnosed as tuberculosis so we always need evidence‐based medicine in our medical life. Abstract Distinguishing between Hodgkin's Lymphoma and tuberculosis is challenging. A 23‐year‐old patient has been diagnosed with tuberculosis; based on clinical and radiological findings. After the therapy, her condition worsened. Cervical lymphadenopathy was detected. A biopsy was performed and the diagnosis was classical Hodgkin lymphoma. After the treatment, the patient improved significantly.