The basic purpose of this research study determines the research on the application of information technology in pharmaceutical sectors. This research study was conducted in the US pharmaceutical sectors. The research study is based on primary data analysis; these data were collected from different pharmaceutical sectors. Information technology is an independent variable, and pharmaceutical sectors, including organization performance, industrial innovation and production, and supply chain management, are all considered dependent variables. The research study used smart PLS software and presented different results, including composite reliability, validity analysis, R square values, indicators correlations, significant analysis, and the smart PLS Algorithm model. Overall results found that information technology plays a vital role in the pharmaceutical sector and presents that significant analysis with each other. In addition, the organization's performance shows a positive and significant relationship. Supply chain management also directly relates to industrial innovation, and production significantly affects industrial sectors.