Senile dementia is a neurodegeneration disease characterized by loss of memory, attention and cognitive functions. Lipoproteins are large lipid and protein complexes that play a major role in carrier of lipophilic and lipid molecule in plasma and central nervous system. The systemic hyperlipidemia may damage the Blood brain barrier via inflammatory and other mechanisms, with consequent leakage of serum lipoproteins. Inflammatory cytokines, and other amyloidogenic factors increases oxidative Stress and has important role in attention, cognition. In the present study we evaluated the levels of lipoproteins in Alzheimer's dementia patients, and observed significantly higher levels of lipoproteins in Alzheimer's dementia patients compared to healthy controls (P<0.001). The present study conducted on 50 healthy controls and 50 Alzheimer's dementia patients by using standard methods.

The senile dementia is a neurodegenerative disease characterized by loss of memory, attention and cognitive functions. The oxidants- antioxidant plays important role by several mechanism by reducing toxic Amyloid-β in neurons The Alzheimer's disease is due to Amyloid-β deposition in the brain and production of neurofibrillary tangles. Amyloid-β induces reactive oxygen species in brain of Alzheimer dementia patients. In the present study we evaluated the levels of Superoxide dismutase, Glutathione peroxidase, Catalase, Vitamin C and Vitamin E and Vitamin B6 in Alzheimer dementia patients. It has been observed lower levels of Enzymatic, Non-Enzymatic Antioxidants and increased serum levels of malondialdehyde significantly in Alzheimer's dementia patients as compared to healthy controls (p < 0.001). Thus, altered oxidative stress markers may play important role in neurodegenerative diseases like Senile dementia. Serum levels of Superoxide dismutase, Glutathione peroxidase, Catalase, Vitamin C and Vitamin E and Vitamin B6 and Malondialdehyde (indicator of Lipid peroxidation) were measured using standard methods in 50 healthy controls and 50 Alzheimer's dementia patients.