Since products are subjected to a random variable stress-strength, their reliability must be determined using the stress-strength analysis. Unfortunately, when both, stress and strength, follow a Weibull distribution with different shape parameters, the reliability stress-strength has not a close solution. Therefore, in this paper, the formulation to perform the analysis stress-strength Weibull with different shape parameters is derived. Furthermore, the formulation to determine the safety factor that corresponds to the designed reliability is also given. And because the relationship between the derived safety factor and the designed reliability is unique, then because reliability is random, the derived safety factor is random.