An improved, safe, and scalable isolation process for (substituted) pyridine and quinoline N-oxides in quantitative yields along with high purities using the m-CPBA–NH3(g) system is described. The safety was assessed by reaction calorimetry and differential scanning calorimetry studies for possible hazards during the conversion and isolation steps. Careful interpretation of the data substantiated the safety and scalability. The process flow is simplified to meet the industrial requirements of safety, cost-effectiveness, and utility minimization. The reaction was safely demonstrated at a 2.5 kg scale.

Spectral data for 2a−2t, 3a−3f, and recovered NCBSI (PDF) FAIR data, including the primary NMR FID files, for compounds (ZIP) 2a−2t, 3a−3f, and recovered NCBSI ■ AUTHOR INFORMATION

No abstract

No abstract

No abstract