Introduction: Naproxen is a non-steroidal anti-inflammatory drug mainly used to treatinflammation, pain, and fever of various etiology. Scientific studies conducted over the lastfive years have shown, that its introduction significantly influenced neoplastic processes inthe in vitro and in vivo studies carried out within cell cultures and animal models.Aim of the study: Our aim was to review the theses, extract and present the influence ofnaproxen and its derivatives in signaling pathways involved in the initiation, promotion andprogression of cancer as well as to indicate potential directions for further research.Methods and materials: We have reviewed the theses in the bibliographic PubMed database,using the keywords: „naproxen”; „naproxen derivatives”; „cancer”; „cancer treatment”„cancer prevention”.Results: In addition to the well-known mechanism of inhibiting COX, there are scientificproofs of the activity of naproxen against other molecules, such as PI3-K(phosphatidylinositol 3-kinase), GSK-3β (glycogen synthase kinase-3β), NFκB (nucleartranscription factor κB), MMP ( metalloproteinases), NO (nitric oxide) involved in neoplasticprocesses.Conclusion: Conclusions drawn from the analysis of specific molecular activities of naproxenand its derivatives against neoplastic processes are promising. However, more preclinicalresearch is needed to confirm the effectiveness, practical applicability and to assess the sideeffects of the therapy, before starting the clinical trials in humans.

Introduction: Gabapentin is a drug used for monotherapy or adjunctive therapy of simple and complex partial epileptic seizures in adults and children. It is also used to treat neuropathic pain for adults. There are reports in the medical literature of the effective use of gabapentin in the treatment of other conditions. Let's take a closer look at its therapeutic potential.Aim of the study: The overview of current literature knowledge about the usage of gabapentin in various medical conditions within the fields of toxicology, dermatology, gynecology, psychiatry branches' issues, with indicating the potential abuse. Materials and Methods: We reviewed the literature available in the PubMed database, using the keywords.Results: Gabapentin is an anticonvulsant drug structurally similar to gamma-aminobutyric acid (GABA). It is considered to be a centrally acting analog of GABA, nevertheless, it presents a different molecular mechanism comparing to the other drugs that affect GABA-ergic transmission. The registered indications for its use are the treatment of seizures within adults and children and neuropathic pain in adults. The literature reveals that gabapentin is also used in the treatment of alcohol abuse disorders within the patients with alcohol withdrawal symptoms, the treatment of pruritus, hot flashes during menopause and the treatment of anxiety disorder. Summary: Due to the ambiguous effects of gabapentin usage, it can be applied to treat various medical conditions. Nevertheless, the usage of this drug described in the literature requires additional studies on a larger group of patients to confirm the findings.

Introduction: Contrast-induced nephropathy is one of the most serious adverse effects of radiocontrast agents usage. It is currently listed in the literature as the third most common cause of iatrogenic acute kidney injury. Aim of the study: The aim of this study is to provide an overview of the extent, severity and prevention of CIN. It is to shed a broader light on this disease entity and be a helpful resource in the future for other clinicians struggling with CIN. Methods and materials: A literature review was conducted using the PubMed database, using the keywords: "contrast-induced nephropathy"; "acute kidney injury"; "contrast media". Results: Pathogenesis of CIN is not entirely clear. There are many risk factors being e.g. diabetes, chronic kidney disease, advanced age (patients over 75 years old). Prevention methods include restricting contrast volume to a minimum, balancing the patient's volaemia before contrast administration or perioperative saline hydration to normalise volaemia. Conclusion: CIN is a significant health problem, which can be a life threat. Despite the fact that the exact pathogenesis of the condition still remains unknown, the CIN prophylaxis becomes more and more effective due to better recognition of risk factors and the usage of adequate prevention measures appropriate to the patients' condition. More studies, with larger test groups, are needed to better define both the pathomechanism of contrast-induced acute kidney injury and new, more effective ways of prevention and treatment of this condition.

Introduction: Cardiovascular diseases (CVDs) remain major problem in modern medicine. According to World Health Organization they are the leading cause of death. Despite increased awareness about impact of healthy lifestyle,  mortality still remains on high level. Cardiovascular diseases requires multidisciplinary treatment. One of those aspects is determinate an appropriate diet.   Purpose: The aim of this systemic review is to collect, evaluate and summarize the information on fasting mimicking diets and it is effect on therapy and prevention in cardiovascular diseases. Material and methods: Analysis and review of available literature. The search of articles in popular scientific databases such as PubMed, Google Schoolar WHO database State of knowledge: Risky behavior include unhealthy diet, tobacco use, physical inactivity, alcohol abuse. Those behaves lead obesity, raised blood pressure, hyperglycemia, dyslipidemia. Those factors have significant impact on the increase of cardiovascular diseases in the population. Fasting and calorie restriction are becoming more and more popular. Results: Many studies indicate that fasting mimicking diet can prevent from excessive fat accumulation, obesity, diabetes, dyslipidemia, hypertension As a result it decreases probability of cardiovascular diseases. Those diets not only support weight loss, but also can help maintain good health  and extend lifespan.