PURPOSE: To study clinical characteristics of Retinoblastoma and analyze the occurrences of patient survival and globe salvation. METHODS: This is a prospective and non-randomized study involving retinoblastoma patients at a tertiary institute from May, 2017 to May, 2019. All patients underwent comprehensive medical assessment and illness management investigations. The given treatment was recorded, including focal therapy, enucleation and chemotherapy. RESULTS: Leukocoria was the foremost common presentation (60.68%) followed by proptosis (12.3%). The patient survival rate was 87.7% whereas globe salvation was at 23.2% (19 eyes). CONCLUSION: Most patients came for clinical examination for rst time at a later stage of disease, having high risk clinical features such as positive family history, hyphema, and large tumor volume. More awareness and early stage diagnosis are of prime importance in order to achieve globe salvation in retinoblastoma.