Cefquinome is a fourth-generation Cephalosporin approved for use in animals exclusively. The objective of this study was to explore the relationship of cefquinome pharmacokinetic/pharmacodynamic (PK/PD) indices with resistance selection of Staphylococcus aureus ATCC25923 in an in vitro model. Six dosing regiments of cefquinome at an interval of 24 h for three consecutive times were simulated, resulting in maximum concentrations (Cmax) from 1/2 to 16MIC and terminal half-lives (t1/2β) of 3 and 6 h, respectively. The in vitro sensitivity of S. aureus was monitored by bacterial susceptibility and dynamic time-kill curve experiments over the six cefquinome concentrations. The correlation between changes in bacterial susceptibility (MIC72/MIC0) and the percentage of time within mutant selection window versus dosing interval (TMSW %) was subjected to the Gaussian function and regression analysis. Our results favored the consensus that time above MIC (T > MIC) was recognized as an important PK/PD parameter of cephalosporins for antibacterial efficiency. Cefquinome reached the maximum killing effect when T > MIC% attained approximately 40∼60%. The subsequent correlation analysis demonstrated that resistant S. aureus ATCC25923 was easy to occur when TMSW% attained an index of about 20% with t1/2β of 3 h after multiple dosing, and 40% with t1/2β of 6 h after multiple dosing, respectively.

While several studies have investigated the effect of employees’ need for achievement on their work‐related outcomes, how leader‐follower congruence in need for achievement is related to critical workplace outcomes remains underexplored. Integrating person‐environment theory and similarity‐attraction theory, this study investigated the influences of leader‐follower congruence in need for achievement on followers’ job performance and job well‐being through the mediating effect of leader‐member exchange (LMX). Using cross‐level polynomial regression and response surface analysis to analyze the data from 391 leaders and 1,124 followers, we found that leader‐follower congruence in need for achievement had a positive effect on followers’ job performance and job well‐being though the mediating role of LMX. The theoretical and managerial implications are further discussed.

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