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A nineteen-year-old Bahraini male with a diagnosis of confluent and reticulated papillomatosis received numerous treatments with minimal response. The patient responded favorably to the treatment of oral minocycline for 6 weeks plus topical mupirocin and has remained since then in remission. Confluent and reticulated papillomatosis (CRP) is a rare chronic skin disease which usually affects adolescents. The patient seeks treatment only for cosmetic reasons.The diagnosis of CRP should be considered if the lesion does not respond to antifungal treatment.

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