1 The pharmacology of the acute hyperthermia that follows 3,4-methylenedioxymethamphetamine (MDMA,`ecstasy') administration to rats has been investigated. 2 MDMA (12.5 mg kg 71 i.p.) produced acute hyperthermia (measured rectally). The tail skin temperature did not increase, suggesting that MDMA may impair heat dissipation.

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These data demonstrate that MDMA when injected directly into the brain produces 5-HT release but no neurotoxicity, suggesting that it must be metabolised peripherally in order to produce compounds that induce free radical formation and neurotoxicity in the brain.

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