Background: Asthma is a common health problem lead to impaired quality of life and disability Aim: Was to evaluate the effect of implementing respiratory guidelines on asthmatic patient. Subjects and Method: Design: A quasi-experimental study was conducted at Chest Intensive Care Unit at Tanta University Hospitals. Subjects: Purposive sample of 60 adult patients with asthma and divided into two equal groups 30 patients in each group. Group 1(study group) and group 2 (control group). Tools of the study: Two tools were used tool (I) Structure Interview Schedule, Tool II Respiratory functions assessment sheet. Results: There was a statistical significant improvement in the level of patients knowledge about asthma ,the majority of study group (83.3%) improved to mild persistent asthma, the majority (96.7%) of the study group changes from abnormal breathing sound to clear sound, more than two third (70%) of study group improved in dyspnea scale to first grade. Conclusions: The results concluded that implementation of respiratory guidelines associated with a significant improvement in the total mean scores of patients' knowledge, asthma severity and spirometry readings in study group rather than control group Recommendations: It was recommended to consider respiratory guidelines when planning a routine care for asthmatic patient , apply the respiratory guidelines on a larger probability sample acquired from different geographical areas in Egypt for generalization.