BACKGROUND: Fatigue is one of the most common problems experienced by chronic kidney disease (CKD) patients undergoing hemodialysis. The application of intradialytic exercises can be the best solutions to overcome fatigue related to CKD. CASE PRESENTATION: A 50-year-old male patient with CKD, who complained of severe fatigue, was selected in case study. The FACIT Fatigue Scale questionnaire and clinical indicators were measured before and after intervention. The intradialytic exercise was administered at 3rd hour of hemodialysis for 4 sessions in 2 weeks. Each session required 30 minutes, containing warming up, main exercise and cooling down. After two weeks intervention, there was an improvement of fatigue score (16 to 29) and reduction of weakness, tiredness, washout feeling, sleepy, and tiredness on eating. Moreover, the clinical indicators showed positive improvement after the intervention. CONCLUSION: Thus, intradialytic exercise is practically promising to minimize fatigue related to CKD among patients undergoing hemodialysis. Hemodialysis nurses or other health care providers could utilize this evidence as a program to reduce the fatigue related to CKD.