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A new composite nanofiber of polyacrylonitrile doped with copper benzene-1,3,5tricarboxylate metal-organic framework was fabricated by electrospinning and used as a microsorbent in the solid-phase extraction of trace tetracycline. The chemical structure of the adsorbent was studied by X-ray diffraction, scanning electron microscopy, Fourier transform infrared spectroscopy, Brunauer-Emmett-Teller surface area analysis, and Barrett-Joyner-Halenda pore size and volume analysis techniques. The significant parameters of the method including desorption solvent kind and volume, adsorbent mass, pH, and salt percentage were investigated. At the optimized conditions, the linear range was 8-1000 μg/L with a determination coefficient (R 2 ) of 0.9954. The limits of detection and quantification were 2.40 and 8.00 μg/L, respectively. The inter-and intraday precisions were 4.7 and 3.4%, respectively. The developed extraction method was followed by high-performance liquid chromatography and applied for the determination of tetracycline in human blood plasma, and good relative recoveries (97.3-104.5%) were obtained. K E Y W O R D Santibiotics, electrospun composite nanofibers, high-performance liquid chromatography, metal-organic frameworks, polyacrylonitrile 1500

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