This study aims to identify the relationship between caregiver burden of patients with schizophrenia and caregiver quality of life (QOL). A cross sectional study involving 222 caregivers patients with schizophrenia was conveniently recruited from the psychiatric clinic of a mental health hospital in Malang Indonesia. Caregiver Burden Inventory Scale and Schizophrenia Caregiver QOL was used to assess the level of burden and QOL among the caregivers respectively. Descriptive statistics was used to determine caregivers' socio-demographic characteristic and the level of caregivers' burden and QOL. Spearman Rho correlation test was conducted to determine the relationship of caregiver burden and caregiver QOL. About 59.6% of schizophrenia caregivers experienced moderate to severe level of burden. The results showed that there was a significant, strong and negative relationship between the caregiver burden and QOL (r = -0.434, p \ 0.001). Most of the participants reported emotional burden and moderate QOL especially psychological and physical QOL, well-being, relationships with friends, and material burden. The findings indicated the higher the caregiver burden, the lower the QOL experienced by family caregivers of individuals with schizophrenia. It is necessary to improve the mental health nursing services for schizophrenia caregivers by providing mental health counseling, and developing support groups for them.