Este trabajo fue recibido el 5 de Marzo de 2016 y aceptado para ser publicado el 5 de Septiembre de 2016. ARTÍCULOS ORIGINALESFactores determinantes del estado nutricional del folato y el rol de la variante genética C677T de la enzima metilen tetrahidrofolato reductasa (MTHFR) Determinants of folate nutritional status and the role of the genetic variation of C677T methylene tetrahydrofolate reductase (MTHFR) enzyme

Calcium as a nutrient involved in the synthesis and localization of proteins that facilitate iron uptake and effl ux in enterocytes El calcio como nutriente implicado en la síntesis y localización de proteínas que participan en la captación y efl ujo del hierro en los enterocitos ABSTRACT Iron defi ciency is the most common type of nutritional defi ciency in the world, and calcium intake is low in many populations. Developing a supplement that contains both micronutrients would be an excellent method to prevent iron defi ciency and increase calcium intake. Human and cellular studies have shown that calcium inhibits iron absorption. Currently, the mechanisms underlying this inhibitory effect have not been elucidated. Because calcium is involved in cell signaling pathways, it may affect the regulation of the expression or localization of proteins involved in iron uptake and effl ux in enterocytes. The aim of this review was to describe the processes involved in the absorption of dietary iron and the regulation of the expression and activity of proteins involved in this absorption. Additionally, the potential mechanisms by which calcium affects the expression and localization of these proteins are also discussed.