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Currently, nanotechnology plays a key role for technological innovation, including the construction sector. An exponential increase is expected in its application, although this has been hampered by the current degree of uncertainty regarding the potential effects of nanomaterials on both human health and the environment. The accidents, illnesses, and disease related to the use of nanoproducts in the construction sector are difficult to identify. For this purpose, this work analyzes in depth the products included in recognized inventories and the safety data sheets of these construction products. Based on this analysis, a review of the recommendations on the use of manufactured nanomaterials at construction sites is performed. Finally, a protocol is proposed with the aim of it serving as a tool for technicians in decision-making management at construction sites related to the use of manufactured nanomaterials. This proposed protocol should be an adaptive and flexible tool while the manufactured nanomaterials-based work continues to be considered as an “emerging risk,” despite the expectation that the protocol will be useful for the development of new laws and recommendations for occupational risk prevention management.

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