The Kidney is vulnerable organ to the drug toxicity, due to the interstitial accumulation of toxic agents, expose the kidney to higher concentrations. The nephrotoxicity develops by a variable degree renal failure, it may be evolved quickly and spontaneously towards the terminal stage and unfortunately lately discovered. Following the studies of indesirable effects of an unwanted circumstance at the EHUO's pharmacovigilance service; we could show the involvement of many nephrotoxic substances as Nonsteroidal anti-inflammatory drugs, during the aggravation of the chronic end stage of the renal failure. As a conclusion, and to reduce the incidence of the renal complications, it is essential to prevent the occurrence of the iatrogenic-based nephrotoxic effects, because that can be a real primary prevention, which is why the recommendations while using this drugs must be respected.