Introduction: Amphetamines/methamphetamines are among the most significant central nervous system stimulant drugs of abuse. Agitation can masquerade very important complications of their abuse that can be life-threatening. Case Presentation: We present a case of acute inhalational toxicity with amphetamine/ methamphetamine who was followed and treated by our residents for almost 12 hours for agitation. Conclusions: His abdominal computed tomography showed a fatal complication later. Complete evaluation of the heart, brain, and abdomen is warranted in every amphetamine or methamphetamine-intoxicated patient who refers with loss of consciousness and agitation.