Background and Objectives: Pre-hospital emergency staff face stressful environments. Job stress management can make employees stay in their occupations and provide appropriate services to patients as soon as possible. Therefore, the present study was conducted with the aim of determining job-related stress and its management methods among pre-hospital emergency staff in Iran. Materials and Methods:In this systematic review, published English and Persian studies without time limitation were searched and reviewed electronically in Persian and English databases from PubMed, Web of Science, Scopus, SID, Magiran, and Google scholar using related keywords. After removing duplicate and unrelated articles, the quality of the articles was evaluated by the authors based on the Strobe checklist. Finally, the narrative synthesis method was used to combine the data.Results: After screening, among the 113 studies, 12 studies reached the final synthesis stage based on the inclusion and exclusion criteria. Most of the studies reported moderate levels of occupational stress. Individual, occupational, organizational, and environmental factors were effective in the occupational stress of employees. Conclusion:Pre-hospital emergency workers face stressful situations on average in Iran. Using strategies such as educational intervention programs, gratitude programs, and management measures such as reducing work shifts and improving comfort facilities can help reduce the occupational stress of employees working in pre-hospital emergency centers.