No abstract

Highlights7 of 9 patients with GGE reduced ≥ 50% their tonic–clonic seizure frequency on LCM.All 7 patients remained seizure free for > 1 year, and 2 of them for > 5 years.In 2 of the 9 patients, both with Juvenile Absence Epilepsy, absences aggravated.One aggravation consisted on a myoclonia and absence status, in a patient with no history of myoclonia.VEEG paralleled clinical improvement but didn't change in a case of absence worsening.

Anti‐N‐methyl‐D‐aspartate receptor encephalitis is a severe, potentially treatable, disorder and prognosis depends on early recognition and prompt immunotherapy. We report a case of anti‐N‐methyl‐D‐aspartate receptor encephalitis with atypical age and gender, and a characteristic electroencephalographic pattern that supported the diagnosis. A 66‐year‐old male presented with psychiatric disturbances and focal seizures with alteration of consciousness, and progressed to a state of akinetic mutism. Auxiliary tests were negative or non‐specific for anti‐NMDAR encephalitis. Electroencephalographic monitoring revealed a unique pattern; the extreme delta brush. The patient improved with immunotherapy and was asymptomatic at six months of follow‐up. Ancillary testing was positive for anti‐N‐methyl‐D‐aspartate receptor antibodies. Extreme delta brush is a recently described electroencephalographic pattern presenting in only one third of patients with anti‐N‐methyl‐D‐aspartate receptor encephalitis. The identification of this pattern, as in our case, may guide early diagnosis and treatment of anti‐N‐methyl‐D‐aspartate receptor encephalitis.

No abstract

No abstract